Physiology 3140A Lecture Notes - Lecture 4: Vasopressin Receptor 2, Melanocortin 4 Receptor, Metabotropic Glutamate Receptor

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Same gpcr can couple to multiple g proteins. Lysophosphatidic acid (lpa) (cid:374)atu(cid:396)e"s si(cid:373)ple lipid (cid:373)ole(cid:272)ule fou(cid:374)d i(cid:374) the (cid:271)lood. Lpa binds to lpa1 which can bind to multiple g proteins: regulates multiple processes (eg. cardiovascular, brain, reproduction) Dopamine neurotransmitter in regulating movement, cognition, reward-motivated behaviour. Just understand one is increase in camp and one is decrease. Gpcrs: spontaneous (basal) activity: spontaneous or intrinsic activity that is the receptor spontaneously adopts an active configuration and signals in the absence of agonist, purpose of agonist is to stabilize the active confirmation, ex. See angiotensin receptor: minimal basal activity: ex. See metabotropic glutamate receptor: high basal activity (need this for memory and learning which explains high activity in absence of ligand) Disease linked to gain-of function mutations of gpcrs: arginine vasopressin receptor 2. Increased constitutive activity leads to nephrogenic syndrome of inappropriate antidiuresis: luteinizing hormone receptor. Increased constitutive activity leads to male-limited precocious puberty: kiss 1 receptor, decreased desensitization leads to precocious puberty.