Physiology 3140A Lecture Notes - Lecture 17: Cholera, Fluoride, Adenylyl Cyclase
28 Dec 2017
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Document Summary
G protein-coupled receptors (gpcrs) form largest family of integral membrane receptor proteins in humans just greater than 2% of genome. Enormous diversity in ligands that activate g protein-coupled receptors (gpcrs) Gpcrs respond to ligands as diverse as light, smell, taste, hormones, neurotransmitters, ions, nucleotides, small peptides, large glycoproteins, fatty acids, amino acids, and pheromones: there are small and large molecules, proteins, fatty acids, etc. The same ligand can activate multiple different receptors in the same family. Receptors are in families there can be multiple receptors for an individual ligand: each of the receptors can have a different outcome. Examples: 9 distinct receptors are activated by adrenaline, 5 receptors are activated by acetylcholine, 7 receptors are activated by glutamate, 15 receptors are activated by serotonin. Diversity of physiological responses stimulated by gpcrs (short list) Receptor can be connected to different intracellular signaling molecules and pathways and they can lead to different outputs.
