Physiology 4530A/B Lecture Notes - Lecture 3: Bone Resorption, Decarboxylation, Osteoclast
8 Feb 2018
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Document Summary
The skeleton in the context of the entire body: bone formation in ectopic sites. Fop, poh: skeleton and whole body metabolism. Problem: lose plasticity of bvs: heterotopic ossification after trauma. Soft tissues turn into bone instead of normal repair common: genetic syndromes: Vascular calcification: amorphous calcification and/or formation of cartilage/bone in cv tissues such as atherosclerotic plaques, the medial layer of large arteries, and cardiac valves. Amorphous calcification: mineralization of bv wall with no cartilage or bone cells associated with it. Developmental: pathways mentioned in lecture 1: specific mechanisms triggering and driving vascular calcification are not well understood, potential therapeutic strategies include prevention of hyperlipidemia and other metabolic effects. Factors in vascular calcification: show the complexity in factors involved in vascular calcification don"t memorize, different genes, development and metabolic processes involved. Fibrodysplasia ossificans progressiva fop: formation of cartilage and then bone in soft tissue i. e. muscle. A lot of abnormality in toe initially.
