Physiology 4530A/B Lecture Notes - Lecture 2: Positive Feedback, Collagen, Joint Replacement

• School: Western University
• Department: Physiology
• Course: Physiology 4530A/B
• Professor: Frank Beier

Document Summary

Osteoarthritis (oa: present in 10-12% of all adults, major contributor to disability and loss of independence, large impact on individual, health care system and society. Operation, clinic costs, loss of productivity, etc. Live longer with disease: co-morbidity is issue for mortality. Chronic pain: no effective treatments, only mitigation of symptoms. The aging population: canada now has more seniors than kids under 15, symptomatic knee oa prevalence rises exponentially in 4th and 5th decades who. Same in males and females: majority of symptomatic knee oa starts bw 30-55 years of age. Decline around 45-50: treatments: painkillers, physiotherapy, exercise, joint replacements, etc. Oa tool: weight loss: can decrease symptoms by ~30, opioids: mild opioids can be helpful with acute pain management, corticosteroids: knee injection treatment, treatments can(cid:495)t stop progression, only manage symptoms. Boney joint: knee synovial joint. Synovial: lining of joint & produce fluid for lubrication & clears debris out of joints via drainage: where infection can occur.