Psychology 3316F/G Lecture Notes - Lecture 13: Septum Pellucidum, Psychiatric Genetics, Gaba Transporter 1
29 Dec 2017
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Wgs (whole genome sequencing) assesses both common and rare variation across both snps and vntrs large samples are required because of the number of tests conducted: psychiatric genomics consortium (pgc; http://pgc. unc. edu) Dopaminergic, serotonergic, and hpa-axis molecular genetics of ptsd: Dopaminergic system (i. e. , drd2, drd3, drd4, dat1); 14 studies showing inconsistent results possibly relating to bdnf and comorbidity with substance abuse. 2009); results may also be specific to various ethnicities (e. g. , European americans but not african americans) and women vs. men. Most often studied is hpa-axis, where several studies report variants on fkbp5 associated with increased risk for ptsd, other variants have also been found (i. e. , nr3c1, crh, crhbp, crhr1); may also be significant only in women. Cnr1, oprl1, oprm1, nos1ap, comt, oxtr: associated with catecholamine degradation, cannabinergic, opioid systems, the s, d, and hpa axis systems exert some of their effects through these systems.
