BI110 Lecture Notes - Lecture 7: Integral Membrane Protein, Phospholipid, Enzyme

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24 Oct 2016
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Cells and organelles need barrier to separate internal and external contents. In order to keep compartments distinct and separate. Ability to exchange some molecules/ions between compartments. A permeability barrier that consists of: phospholipids, glycolipids, sterols (except in bacteria, cholesterol (animals, ergosterols (fungi, phytosterols (plants, membrane proteins. Integral proteins (usually transmembrane: peripheral membrane proteins (not embedded into the hydrophobic core of the bilayer. Primary molecules that make up biological membranes. Amphipathic molecules: phosphate-containing hydrophilic head groups, hydrophobic fatty acid (hydrocarbon chain) tails. Integral membrane proteins are amphipathic, containing both hydrophobic and hydrophilic amino acids. Hydrophobic domains in the trans-membrane region of an integral membrane protein stabilize it within the lipid bilayer. Some amino acids are hydrophobic and some are hydrophilic. Hydrophobic domains form the trans-membrane region(s) of integral membrane proteins, and. Integral membrane proteins contain hydrophobic and hydrophilic amino acids stabilize them in the membrane. A transmembrane domain is ~20(+/-) amino acids long.

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