BI226 Lecture Notes - Lecture 25: Cystic Fibrosis, Neurofibromatosis, Mendelian Inheritance
Document Summary
Large family pedigree used to locate the huntington disease (hd) gene. Mapping of huntington disease : detection of linkage between the dna marker g8 and the. Hd locus: segregation of the g8 dna marker (four alleles - a, b, c, and d) in a large. The lod score is a statistical tool for studying linkage: used to determine if data are sufficient to conclude with confidence that a disease gene and a marker are linked. Lod = log prob. (observed results if loci are linked at a given rf) Cystic fibrosis (cf) symptoms were first described in 1938, but the genetic cause of the disorder was not known, and there was no effective treatment for the 1/2000 caucasian north. In 1989, geneticists were able to pinpoint a precise locus for the cf gene by looking directly at. The discovery was a collaborative effort led by drs.
