PS268 Lecture Notes - Lecture 18: Cell Membrane, Anticholinergic, Psilocybe Mexicana
Document Summary
Cns stimulant, intense feelings of pleasure, increased alertness, decreased need for sleep and appetite. Coca a bush that grows in andes and produces cocaine (active chemical in plant: erythoxylon coca leaves are less than 1% by weight cocaine. Psychoactive effects made stronger by adding calcified lime. Mariana coca wine praised by pope. Coca paste crude extract containing cocaine in a smokeable form. Cocaine hydrochloride most common form of pure cocaine, stable, water soluble. Crack (rock) street name for simple cocaine base. Cocaine blocks the reuptake of dopamine, norepinephrine and serotonin; prolonging the effects. Cocaine stays in body for half-life of about an hour, metabolites completely gone ( urine test) eight hour half-life. Acute toxicity : profound cns stimulation, convulsions, respiratory or cardiac arrest, cocaethylene chemical formed from cocaine and ethanol administered together. Irritated nasal septum over snorting with cut: smoking with high heat / makeshift devices cuts/ scars, open sores, paranoia, restlessness.
