PS268 Study Guide - Midterm Guide: Atropa Belladonna, Oxycodone, Insite
Document Summary
Amphetamines: history, china: ma huang/herbal tea, active ingredient ephedrine, discovered in 1930s, early uses, asthma treatment, narcolepsy treatment, reduce hyperactivity in children. Improve efficiency of soldiers: various forms, speedball: heroin + cocaine, speed: street name for cocaine, methamphetamine: liquid form for injection, crank: illicit lab-made methamphetamine. Ice/crystal meth: smokeable meth crystals: methamphetamine, man-made, highly addictive, cold medicine, white powder or pill form, smoked, injected, snorted, effects: Inhalation: 90% bioavailability: oral: 67% bioavailability, 100% gone from body after 2 days, high dose = tachyphylxis (rapid tolerance) Intranasal: 79% bioavailability: medical uses, depression (not used today, weight control, narcolepsy treatment, hyperactive children, smart pills : improved mental performance. Increased athletic performance: causes for concern, acute toxicity. Impaired decision making: panic & paranoia (high dose, violence, slight brain damage, destroys catecholamines, chronic toxicity, paranoid psychosis, sleep deprivation, compulsive & repetitive actions, dependence potential, high abuse potential, limited withdrawal symptoms.
