BIOL 2020 Lecture Notes - Lecture 23: Cirrhosis, Biliary Tract, Hepatitis
8 May 2020
School
Department
Course
Professor
Document Summary
5" nucelotidsase specific marker for occlusion of biliary tract and cholestasis. Ldh can be used as marker of metastasis of other cancers to the liver as well as congestion to the flow of blood to the liver (and values would rise). So, ldh is still a player but not a major player. Three players that are specialty causes of chirrosis. Can be due to alcohol abuse , hepatitis, auto-immune disordersetc Here are some specific metabolic disorders that can also lead to cirrchosis: alpha 1- antirypsin when present in diminished capacity, other proteases run un-checked and this can lead to cirrhosis. Caeruloplasmin decreaces: iron, tibc (total-iron binding capacity), ferritin - can measure binding protein (fncitonal protein) or mass assay. The iron is stored in a number of tissues, including the liver, and this can lead to liver cirrhosis. Hemochromatosis is frequent in individuals of northern european descent (1/100).
