BIOL 2020 Lecture Notes - Lecture 6: Globin, Proline, Transport Protein
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Lecture 6 – Hemoglobin and Protein Structure
Hemoglobin
Abundant present in your blood
Exhibits quaternary structures
Transport protein
Oxygen carrying molecule of vertebrates; transports it to
peripheral targets around the body
Heterotypic
o2 a-subunits: a1 and a2
o2 B-subunits: B1 and B2
odon’t necessarily correspond to secondary structure of
hemoglobin
the subunits are referred to as globin fold
blue dimer (closer to us) is a1B2 dimer
the two dimers come together to form a tetromer
secondary structure of a globin fold consists of a-helices little
barrels
for each globin fold 8 a-helices at the end there’s a proline
that folds back and continue