BIOL 2060 Lecture Notes - Lecture 45: Paracrine Signalling, Atp Hydrolysis, Nitric Oxide

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Exercise increase cardiac output, decrease resistance to dilate, increase sbp, diastolic remains same, increase in skeletal muscle blood flow. Baroreceptors don"t respond to prolonged changes in map. Receive 22% of cardiac output 1500 l/day. Gfr is 20% of renal plasma flow passes through glomerulus 180l/day. 80% remains in vascular & flows out through efferent = 400ml/min. At the end 99% reabsorbed & retained in venous system to be retuned to heart & 1% excreted. Fully excreted then clearance (inulin) =gfr= 125. If partially reabsorbed clearance = 0-125 like sodium and urea. If not reabsorbed & secreted like h+, k+ & penicillin then clearance = 125-625. Filtration barrier: fenestrated endothelial cells-> basement membrane podocytes filtration slits. Kf is filtration co-efficient- surface area & glomerulus permeability. How is gfr regulated- regulate pgc through arteriole constriction. No constriction, up blood flow, up pgc, up net filtration, up gfr. Dilation decreases blood volume & thus decrease map by increase gfr & net filtration.

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