BIOL 3070 Lecture Notes - Lecture 13: Carbonic Anhydrase, Haldane Effect, Ion Exchange
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Within a fully saturated hb molecule, 1g hb contains ~1. 34ml o2. On average, 15g hb/dl (decilitre = 100ml) 1dl = 1. 34 x 15 = 20. 1 volume % (carrying capacity shown on right side of the figure) Various textbooks display one axis as % hb saturation and second axis as carrying capacity (volume % o2 in the blood) sometimes these 2 axes are expressed separately. Horizontal axis = partial pressure of oxygen in the blood (mmhg) At ~100mmhg = normal po2 of blood at pulmonary capillaries. At ~40mmhg = average resting po2 at systemic capillaries. When a person is at rest, the po2 is ~40mmhg at systemic capillaries. As po2 increases during steep portion of curve, makes it easier to bind/load more o2. As po2 decreases during this steep portion, correspondingly easier to unload o2 to the tissues (due to subunit cooperativity due to the quaternary structure of hb don"t see this in the myoglobin-o2 binding curve!)