CHEM 3050 Lecture Notes - Lecture 1: Oxidative Phosphorylation, Acetyl-Coa, Metabolic Pathway

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CHEM 3050
Lecture 1
ENZYME DYNAMICS & FUNCTION
Living things need to harness energy from the environment in order to carry
out the reactions required for life. Plants use sunlight, we eat food. The
focus of biochemistry and metabolism can be broken down to three
metabolic processes every cell goes through
1) Glycolysis the preferred method of energy harnessing; it is the
breakdown of glucose to pyruvate. Works nicely because carbs are
fastest/most used energy source
2) The citric acid cycle generation of acetyl Co-A; kind of the hub of
metabolism where intermediates are made for other structural
components/processes and where further energy is harnessed
3) Oxidative phosphorylation final step in harnessing energy from food.
By these processes, glucose can be harvested for more than just energy
use; it can be harnessed for use in structural situations (molecular
interactions, cellular structure, etc) and used to make other important
biomolecules (nucleic acids, glycogen, etc)
Even still sugar/glucose is the most direct/efficient input into the energetics
metabolic pathway.
Step 1: Glycolysis
Directly breaking the sugar up; use D-glucose, 2 NAD+(oxidized) & 2 ADP
2 pyruvate, 2 NADH (reduced) & 2 ATP in an overall favourable process
ΔG°’: -29.9kJ/mol
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Document Summary

Living things need to harness energy from the environment in order to carry out the reactions required for life. The focus of biochemistry and metabolism can be broken down to three metabolic processes every cell goes through: glycolysis the preferred method of energy harnessing; it is the breakdown of glucose to pyruvate. By these processes, glucose can be harvested for more than just energy use; it can be harnessed for use in structural situations (molecular interactions, cellular structure, etc) and used to make other important biomolecules (nucleic acids, glycogen, etc) Even still sugar/glucose is the most direct/efficient input into the energetics metabolic pathway. Directly breaking the sugar up; use d-glucose, 2 nad+(oxidized) & 2 adp. 2 pyruvate, 2 nadh (reduced) & 2 atp in an overall favourable process. There are other pathways called feeder pathways that feed into glycolysis from other energy sources either by producing glucose or producing intermediates in glycolysis. Takes place by ten reactions in 2 phases.

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