ENVS 1800 Lecture Notes - Lecture 13: Graphical User Interface

True / False Questions

01. _____ Antibody is composed of 2identical long heavy chains and 2 identical shorter lightchains.

02. _____ Variable (V) and constant(C) regions are part of both heavy and light chains.

03. _____ Variable regions for heavyand light chains from the same antibody molecule are alwaysidentical.

04. _____ Variable region of lightchains are encoded by the DNA sequences that contain rearranged V,D, and J segments.

05. _____ Fc part of the antibody isnot important, F(ab’)₂ fragment has the same binding andeffector capacity.

06. _____ Fab fragments are generatedby alternative splicing.

07. _____ J chain is used as asurrogate light chain during pre-B cell receptor testing forsuccessful V(D)J rearrangement.

08. _____ Binding of the antigen byantibody is stabilized by disulfide bonds.

09. _____ RAG1/2 are always expressedin B cells at high level, because B cells need RAG1/2 to constantlyrearrange their V regions.

10. _____ “N” (non template)nucleotides are added by TdT.

11. _____ The 12/23 rule is appliedduring class switching.

12. _____ For B cells, V(D)Jrecombination occurs only in the bone marrow.

13. _____ The process of somatichypermutation helps to improve specificity of the antibody.

14. _____ In late pro-B cells, Vsegment is rearranged with DJ segments.

15. _____ Failure to eliminateself-reactive B cells may lead to serious autoimmune diseases.

16. _____ Mature, naïve B cellsexpress IgD and any of the other classes of antibody (IgM, IgG,IgA, or IgE) on their surfaces.

17. _____ B1 cells are present in theperitoneal cavity, pleural spaces and brain.

18. _____ AID (activation inducedcytidine deaminase) is expressed only in B cells and it canintroduce breaks in double stranded DNA.

19. _____ Different classes (isotypes)of antibodies have different effector functions, which aretriggered by special receptors expressed by a variety of cells.

20. _____ Plasma cells are terminallydifferentiated cells that produce large quantities ofantibodies.

21. _____ Repeated exposure to thesame antigen eventually leads to immunological exhaustion and lackof immunity, because there is no room for new plasma cells in thebone marrow.

22. _____ Germinal centers arespecialized sites within the bone marrow where Ig genes ofactivated B cells undergo affinity maturation.

23. _____ B cells can present antigensto T helper cells.

24. _____ Co-stimulatory molecules arerequired for efficient generation of memory B cells.

25. _____ Lymphocytes migrate to thelymphoid tissues in response to chemokines.

26. _____ Class switching duringgerminal center reaction is a random process.

27. _____ T cell independent responsescan generate strong and long lasting B cell memory.

28. _____ Fc receptors that arepresent on many different cell types are crucial for removal of thepathogens.

29. _____ The ideal vaccine should bedesigned to mimic the natural course of infection without causingsymptoms of the disease.

30. _____ The protective immunity canbe generated against any pathogen because there is virtuallyunlimited number of possible V regions, thus any antigen can berecognize by an antibody.

Comments on this, i need a paragrapgh on comments abaout this...

Abortion keeps being a controversy because both sides of the spectrum have valid points. The side that is prolife it right about abortion being the termination of an organism. Their believe system states that murdering human being is wrong and since an unborn child is still a human child, then by default this should be condemned as a wrong thing. They also say they are helping the woman themselves because abortion can have “the risk of breast cancer in those who had experienced an induced abortion was 50% higher than among other women” however the same study states “the results across all epidemiologic studies of this premise are inconsistent—both overall and within specific subgroups. The risk of breast cancer should be re-examined”. This means we should not jump in to conclusion because more studies need to be done before accepting something as fact. The side for pro-choice states that a woman should have the choice to make her own decision no matter if it is a good or bad decision. A decision that will change her live completely and most of the time make it harder for a woman to get ahead in life.

I am pro-choice, not because I like terminating live, I am actually pro-live of any type of organisms not just humans, but because woman who phase this problem should have their reason or really are not prepare to have a baby in a modern society, and as Mack T Brown said “The value of a self-represented future resides within the person herself, as a feature of a richly complex mental life". Both sides of the argument go to the extreme to explain their case pro-choice and give the example of a raped woman. Pro-live give the example of that a baby is always a good thing. Both acceptable, however most woman are not in this spectrums, an example that is more relevant is a woman who does not have the emotionally and or financial maturity to make the choice that is to have a child. Physically a girl is ready to have a child when her menstrual cycle begins that is usually around 13. Most people would agree that a girl of that age will not have any type of maturity to take care of even herself less a child. Let’s not go far let’s say a girl of eighteen years old getting out of high school, she may have a rare emotional maturity at that age to have the child but in today’s society impossible without any help from family members to take care of that child. How many hours will she work? How will she take care of the child? How will she go to school to better herself for the future to come? These girls that are asking themselves if they should have an abortion is not because it is something they would like to do, it is a hard decision to postpone taking that live changing decision before they are ready to do it and not be a burden in society.

The current abortion law is strict, so abuse of the law will be very hard to do. In the third trimester a woman would need 2 signatures of two physicians to be able to do an abortion. I personally think that this is great this way we can assure that there is no negligence from any party. The part of the law I do not agree with is that the law says that if during the abortion the baby is born alive they need to offer emergency services. This defeats the purpose of an abortion that as harsh as it sounds it is to terminate the pregnancy cycle before time.

Select the statements that correctly represent the theory ofevolution. Select all that apply.

Evolution is partly about inheritance. Evidence of evolution isseen in structures such as wisdom teeth and the tail bone inhumans. These structures are thought to be “left over” from ourancestors and no longer appear to have any essential function inmodern humans.

Natural selection means that today’s organisms are perfectlyadapted after millions of years of fine-tuning. No further changesare necessary because of all the progress that has been made bynatural selection.

We can see evidence of past natural selection in adaptationssuch as the camouflage of moths perched on the bark of their hosttree. We can also see natural selection at work today if we trackhow populations change in rapidly changing environments.

The theory of evolution does not apply to life today. It isstrictly about the history of life: what happened in the past asseen in fossils.

Scientists disagree about the main ideas of evolutionary theorybecause of incomplete or conflicting evidence.

Question 2

Select one answer.

10 points

The ability or tendency of organisms and cells to maintainstable internal conditions is called

metabolism

homeostasis

emergent property

evolution

Question 3

Select one answer.

10 points

Why do organisms maintain fairly steady conditions within theircells and bodies?

They need to keep conditions stable so that they can obtainfood.

Organisms just change along with whatever is happening in theoutside world, which is usually quite steady.

They must maintain stable conditions to keep their enzymesworking and generally to enable the chemical reactions of life.

Unstable conditions will destroy the DNA in cells; this is themost important risk for a cell facing physical or chemicalstress.

Question 4

Select one answer.

10 points

An organism or cell exhibits ____________ when it maintainssteady internal conditions despite changes in the outerenvironment.

homeostasis

evolution

balance

natural selection

Question 5

Select one answer.

10 points

Which type of molecule best illustrates the very strongrelationship between structure and function in biology?

enzymes

oxygen gas

all kinds of organic matter

water

Question 6

Select one answer.

10 points

Which best expresses how nutrients and energy move throughlife?

Nutrients flow from sunlight to organic matter to heat. Energycycles among all life forms.

Nutrients cycle among all life forms. Energy flows from sunlightto chemical energy to heat.

Nutrients and energy both are continually recycled in a greatcircle of life.

Question 7

Select one answer.

10 points

Which of the following is not a recurring theme in biology?

Living organisms maintain homeostasis.

Energy flows through living systems while matter isrecycled.

Evolutionary processes explain both the unity and adaptivediversity of life.

All of these are recurring themes.

Question 8

Select one answer.

10 points

Which statement about evolution is FALSE?

According to evolutionary theory, you are related to abacterium, to a yeast cell, to a snake, and to a whale. In fact,you are related to every species now alive on Earth, and to fossilspecies like dinosaurs as well.

Evolution occurs constantly, without end; there is no endpointin evolution.

Natural selection acts on genetic differences within apopulation to cause evolution. Individuals do not evolve.

Natural selection is about slow but steady progress. Through it,populations constantly get better-adapted. When this process iscompleted for all populations, evolution will come to a stop.

Question 9

Select one answer.

10 points

Imagine you have a peanut butter sandwich in front of you. Thesandwich is an example of _______.

matter

energy

Question 10

Select one answer.

10 points

You provide your gut bacteria with a warm place to live. Theyprovide you with vitamins and other services. This most directlyrepresents an example of...

shared ancestry of all life

natural selection

homeostasis

interdependence of life