KINE 1020 Lecture Notes - Lecture 1: Left Coronary Artery, Right Coronary Artery, Pulmonary Artery
1 Feb 2016
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Muscle weakness- failure to develop an expected force, somewhat irreversible: Muscle diseases: central (upper/ lower motor neuron disease: motor neurons lying in spinal cord: most common amyotrophic lateral sclerosis, between 50-70 years old: paralysis fast progressing, death within 3 years, infant amyotrophic lateral sclerosis: fatal within one year. Upper motor neuron disease (lack of electrical signal) Many causes including tumors, spinal cord injury, etc. Peripheral neuropathies: degeneration of the axons (core of nerve fibers) Sarcolemme, t-tubule+ - internal membrane functions sarcoplasmic reticulum. Reduced end plate electrical potential with lower electrical input. Nm transmission may be inherited as result of autoimmune disorders. Reduced electrical input results in less signal for calcium release from. Ex: myotonic disease: lack of calcium balance restoring itself. Group of hereditary disorders characterized by progressive muscular atrophy and weakness. Progressive loss of muscle size+ strength caused by loss of muscle proteins later changing to muscle fiber/ tissue death. Measurement of activity of creatine kinase in blood.
