KINE 2475 Lecture Notes - Lecture 2: Acute-Phase Protein, Serum Iron, Hfe Hereditary Haemochromatosis
13 Jan 2020
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Document Summary
Increased elevated serum transferrin (low saturation: low hemoglobin levels, low serum iron (normal is 105 ug/dl)- low specificity. Not strong in diagnosis: low serum ferritin (decrease storage) often seen in infection or chronic inflammation. Body is trying to do what it can to respond to crisis. Less than 20-24% even with higher tf & t. Increased transferrin receptor reflects tissue iron needs (don"t decrease in infection or inflammation) Protoporphyrin is found in hb to which iron binds to. Infection: increased acute phase response; take all available fe from plasma to keep it away from pathogen. Iron supplementation, dietary: fe fortification of wheat flower: canadian wheat flour is enriched with thiamine (vit b1) , riboflavin (vit b2), niacin (vit b3), iron & folic acid. Iron supplements not recommended for non-anemic pregnant women. Clinical trials have failed to demonstrate improved clinical outcomes for the mother or newborn. Supplements can be harmful to individuals with hereditary hemochromatosis or hemosiderosis.
