NATS 1540 Lecture Notes - Lecture 5: Intraabdominal Infection, Ceftazidime, Multiple Drug Resistance
31 May 2020
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Define the pathogens associated with healthcare associated iai. Please list 4 appropriate regimens for this indication. (group 8) Healthcare associated infections tend to have a more diverse array of pathogens and higher likelihood of multi-drug resistance compared with isolates from community- acquired infections. The bacteria that were isolated most often from the infection site and blood cultures include e. coli, streptococcus spp. , and bacteroides spp. However, in patients diagnosed with severe infections, the pattern of bacterial isolates may change and include candida, enterococci, enterobacteriaceae and s. epidermis. Empiric antibiotic therapy for healthcare-associated intra-abdominal infection should be driven by local microbiologic results. To achieve empiric coverage of likely pathogens, multi drug regimens that include agents with expanded spectra of activity against gn aerobic and facultative bacilli may be needed. These include carbapenems (meropenem, imipenim-cilastatin, doripenem), piperacillin- tazobactam, ceftazidime or cefepime in combo with metronidazole. Recommendations for empiric antimicrobial therapy for healthcare-associated complicated intra-abdominal infections.
