NATS 1670 Lecture Notes - Lecture 12: Lamivudine, Nevirapine, Retrovirus
15 Mar 2017
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Only when the mother found to be hiv positive 72 hours later can reduce the infection of baby. They need to be separated; the virus must use a protease. Often 2 reverse transcriptase inhibitors and 1 protease inhibitor. Specific activity where a phosphate needs to bond to an hydro-group. Azt is exactly like thymidine except for the fact that there is no oh. So phosphodiester bond is not going to take place. No other nucleotides can be added to this strand. Viral reverse transcriptase is 100 times more susceptible to inhibition by azt than host cellular dna polymerase. One type of drug involves nucleic acid replication. Azt is going to integrate into the growing dna as well by reverse transcription. Problem: nitrate group is blocking from other nucleotide putting oh. Next nucleotide is not going to create a phosphodiester bond simply because there is no oh. Good blocker of mother to child transmission.
