PHIL 2015 Lecture Notes - Lecture 16: Voltage-Gated Potassium Channel, Voltage Clamp, Reversal Potential
23 May 2020
School
Department
Course
Professor
Document Summary
This will depend on the relative number of channels, their conductances and their open probabilities. If ina > ik, the net current is inward. What name is given to the open probability curve generated? or an inactivation curve. It represents the probability of not being in the inactivated state. Divide each current level by vm ena. It doesn"t. unless all the channels have been inactivated. How does activation curve change when starting potential is altered: discuss the molecular basis of c-type inactivation in voltage gated k+ channels. This occurs when the connection between the movement of the s4 voltage sensor and the s6 in the channel pore is broken following channel activation. The part of the channel that connects these two regions (s4 and s6) is the s4- This causes the s6 activation gate to go back into a position that occludes the pore again.
