PHIL 2130 Lecture Notes - Lecture 9: Benign Prostatic Hyperplasia, Irreversible Antagonist, Essential Hypertension
6 May 2020
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Only work if there is an agonist. Hyperactive prostate and sm leading in urgency to pee. 22 hr half life = longer effect = given less often. This drug specifically targets the sm in the prostate better than the sm in the vasculature. Glaucoma: the production of fluid in the eye. Diuretic to get rid of excess water. Adverse effect: casues pooling of blood orthostatic hypotension. So less blood goes to the brain. Review dose response curve and thus reduce the pressure. Can be absorbed into the systemic circulation even if applied locally to the eye. Concern for chf patients 2 block = vasoconstriction. Antagonism at the 1 receptor so it will treat hypertension. Note: baroreflex means if you reduce bp there will be reflux tachycardia. But bc this drug is also an antagonist at the 1 receptor it blocks the reflux tachycardia. As potent as propranol at 1 receptors.
