PHIL 2130 Lecture Notes - Lecture 5: Fosfomycin, Cholic Acid, Foscarnet
6 May 2020
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Document Summary
Bile acids names usually end in cholate or. Monocarboxylic acid transporter 1 *also on basal membrane. ~ ex. cellular metabolism, signal transduction, nucleic acid/ lipid syn. Inhibited by grapefruit juice (also found in liver for uptake 1b1, 1b3) Coupled with h+ so affected by ph. Looks for peptide bond which is conserved when transported. Peptidomimetic drugs (they look like peptides) they will be better absorbed by this transporter. When there is cellular hydrolysis after absorption the drug is active. Acylcovir: has an aa on it so can use this transporter even though no peptide bond (antiviral). Beta lactam = 4 member ring with carbonyl (seen above) > looks like ganciclovir (right) but missing just one oh. Aa substrates end in "in" "en" or. Except for the dopamine-like substrates methyldopa and l-dopa that go though the aa transporter (look for amino and.
