PHIL 2130 Lecture Notes - Lecture 27: Ground Substance, Lymphatic Vessel, Molecular Diffusion
6 May 2020
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Tissue fluid vs organic molecules (proteogylcans vs adhesive glycoproteins) Gs is gel like substance that fibre embedded in. Medium for molecular diffusion between plasma and icf. Between ecf components: plasma, interstitial fluid, and lymph. Ph, higher than osmotic pressure po, pushes fluid out of bv. Lymphatic vessel always has lowest ph, excess fluid moving out of bv becomes lymph. Edema = excess fluid in interstitial space, no reuptake in venous or lymph clearance. Disruption in normal gradients of ph and po. Comb like structure, bristles, consist of glycosaminoglycans (gags) Unbranched polysaccharides composed of repeating disaccharide units. Attach to core protein, form proteoglycans, tissue specific. Turgidity and ability of ct to resist compression. Very hydrophilic, imparts viscous, slippery texture to ground substance. Cartilage, linked to hyaluronic acid to form agreccan. Adhesive glycoproteins: glue that sticks everything together fibronectin, laminin. Binding sites for collagen, gags, and integrins (transmembrane link glycoproteins) All derived from mesenchyme (osteoblast, endothelial, mesothelial, fibroblast, adipocyte, chondroblast)
