PHIL 2130 Lecture Notes - Lecture 14: Lewis Acids And Bases, Gentamicin, Glucosamine
6 May 2020
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For our purposes: life occurs in aqueous environments: proton transfers in water. A limited, operational definition: acid is a species/functional group that donates proton and becomes ionized, base is a species/functional group that accepts proton and becomes ionized. There are several theories of acids and bases. Arrhenius theory: anything is an acid if it gives of a h+ and anything is a base if it gives of a oh- We are talking about water-based media: such as blood, gi tract, so we will stick to lewis. Lewis theory: talks about electron donors and electron acceptors. Penicillin g weak acid has carboxylic group. Some basic organic chemistry people like to: common acidic group, carboxylic acids, phenols, thiols, alpha hydrogens. Aliphatic alcohols are not acidic: meoh, etoh,etc . Common basic groups: aliphatic amines, aromatic amines (weaker bases) Nitorgens in aromatic systems (heterocycles) are often very weak bases or not at all.
