BIOL2000 Lecture Notes - Lecture 10: Cytosol, Receptor Tyrosine Kinase, Endoplasmic Reticulum

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8 Mar 2016
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February 29, 2016
Lecture 10: Cell: Cell Interactions Part 2

The only difference among cells is the gene expressions involved
The only cells that are susceptible to changes in gene expression are
ones that have receptors

Hormones that cannot diffuse across the plasma membrane rely on
signal transduction pathways
o
o
o

 
oG proteins: trigger the production of intracellular messengers
oEnzyme-linked receptor: triggers activation of proteins in the cell
!
"

#
Are peripheral membrane proteins located inside the cell that are
closely associated with the transmembrane signal
#!#!$
#%&'
GPCR: G-protein coupled receptor; always has a G protein associated
with them on the inside of the lipid bilayer
#()

GTP: has three phosphate groups attached to them
o#
GDP: has two phosphate groups attached
#(*
**#%#!
!*

Steps:
o+
o#
o##!
o#($
,(-
 *
"
Adenylyl cyclase: takes ATP and converts it to form a second messenger
Activated because GTP is bound to it (causes it to changes shape)
"*
./
&'
All of this happens near the membrane
./,0 ,

./ )
.,&'
,01&'
./1
,