BIOL 4510 Lecture Notes - Lecture 8: Polyomaviridae, Papillomaviridae, Lytic Cycle
10 Mar 2018
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Inability to halt proliferation in response to deprivation of growth factors. Increased transport of glucose: tumorigenicity, anchorage independent growth is a predictor of in vivo tumorigenicity, colony growth on a semi-solid agar medium prevents the cells from attaching on the solid substrate of the petri dish bottom. Fully transformed cells are able to form tumors: when cells are non-tra(cid:374)sfor(cid:373)ed they (cid:272)a(cid:374)"t gro(cid:449) o(cid:374) se(cid:373)i-solid agar medium, predicts whether those cells would be tumorigenic or not, test: Induce tumor in one mouse and inject it into another mouse: have transplanted tumor accepted by the host so it can grow. If it is integrated into the cells genome, it will divide as the cell divides. He thought it was these ds versions of the viral genome that could be integrated into the host genome. Retroviruses were given to a group of rna viruses as the flow of info is backward, from rna to dna: rt.
