MCELLBI 110 Lecture Notes - Lecture 14: Rag1, Immunoglobulin Light Chain, Heterotetramer
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24 Feb 2021
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Lecture #14: an immunoglobulin g (igg) molecule, antibodies are made and secreted by b cells. Each b cell makes only one type of heavy chain, which has a specific sequence, and one type of light chain, which has a specific sequence. Rag1-rag2 recombinase is derived from the transposase of an ancestral transposon. V(d)j recombination occurs at specialized sites: vdj recombination is guided by recombination signal sequences (rss), which are inverted repeats (just like the ends of a transposon) The 12-23 rule: to ensure that a light chain v segment joins with a j segment instead of another v segment, deletion can occur only between inverted repeats with different internal spacer lengths. Hmgb2: co-condensin complexes, a complex array of dna protein interactions and dna bending in the rag1-rag2 23-12 rss. Close resemblance of rag recombinase mediated v(d)j recombination and transposase mediated dna transposition. Other processes generate additional diversity at the v(d)j junctions.
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Related Questions
Question 1
The antigen specificity of a BCR...
A. | depends on the isotype of that BCR. |
B. | is the same as the antigen specificity of the secreted form of antibody produced by that cell. |
C. | is different for each of the BCRs on a cell. |
D. | is different for each of the Fab regions of the BCR. |
Question 2
All BCRs on the surface of a B cell in a lymph node...
A. | will have the same type of light chain (kappa/lambda). |
B. | will have the same type of light chain with the same exact amino acid sequence. |
C. | will each have a different type of light chain. |
D. | will have a lambda light chain on one Fab and a kappa light chain on the other Fab. |
Question 3
The isotype of an antibody is...
A. | determined by the light chain. |
B. | another word for an immunoglobulin Fab region. |
C. | determined by the heavy chain constant region. |
D. | determined by the Fc portion. |
E. | None of the above are correct |
Question 4
Characteristics of lgG are...
A. | a molecular weight of 900,000 and 10 antigen binding sites in the secreted form. |
B. | 165,000 molecular weight in the monomeric form but it is usually secreted as dimer. |
C. | the presence of more heavy chain constant regions than most antibodies but the lowest concentration in blood. |
D. | 150,000 molecular weight and the highest concentrations of all antibodies in blood. |
E. | None of the above describe IgG. |
Question 5
Characteristics of lgM are...
A. | 900,000 molecular weight and the secreted form has 10 antigen binding sites. |
B. | 165,000 molecular weight in the monomeric form but it is usually secreted as dimer. |
C | .the presence of more heavy chain constant regions than most antibodies but the lowest concentration in blood. |
D. | 150,000 molecular weight and the highest concentrations of all antibodies in blood. |
E. | None of the above describe IgM. |