ANTH 243 Lecture Notes - Lecture 7: James V. Neel, Insulin Resistance, Sansei
14 Sep 2016
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Document Summary
Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose, which leads over time to serious damage to the heart, kidney. Type 1 insulin dependent when the pancreases does not produce enough insulin on its own. Caused by body"s in effective use of insulin. Now also seeing it in children as young as 8-9yr. Glucose is storage as glycogen in the liver. Normal: pancreases releases insulin into the blood, insulin attaches to receptors on cells which signal the cells to absorb glucose from the blood. Type 2: no response/ insulin resistance- there is no binding to the receptors. Exceptionally efficeient in the intake and/or utilization of food. Selective advantage when hunter and gathers had a feast and famine lifestyle but now it is a mismatch for our current life style. Don"t have strong support for the genes of diabetes. Fetal programming- thrifty phenotype-developmental origin of health and disease hypothesis.
