CAS CH 273 Lecture Notes - Lecture 19: Acetyl-Coa, Phosphofructokinase 2, Citric Acid
16 Dec 2015
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Controlled because : you dont want to waste energy, opposing reactions are different for thermodynamic reasons. Compartmentation: doing this in different tissues as a control mechanism. Two compounds lie at the crossroads acetyl coa and pyruvate only a few tissues can carry out all these reactions (liver) Compounds made to pyruvate can go into gyloconegosis. If a lot of f6p is around then f26p is made. The synthesis of fru-2,6-p2 is performed through the phosphorylation of fructose 6- phosphate using atp by phosphofructokinase 2. This shuts down gluconeogenesis and activates glycolysis (control point) Presence of citrate suggests abundant acetyl coa. Fatty acids inhibit more synthesis of malonylcoa (feedback inhibition) Malonylcoa inhibits transport of acylcoa into matrix where it would be broken down. ** make sure when fatty acid synthesis occurs (cytoplasm) isn"t corresponding breakdown in matrix. Movement between compartments requires number of specific transporters (citrate, carnitine and aspartate were discussed)
