CAS PS 211 Lecture Notes - Lecture 6: Monocyte, Basophil, Blood Vessel
15 Sep 2016
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Document Summary
Following tissue damage, blood vessels dilate in area of damage and permeability increases vasocilation- increases blood flow to damaged area and responsible for redness and heat associated with inflammation. Increased permeability permits defensive substances normally in blood to pass through walls of blood vessels & enter injured area. Phagocytic granulocutes attracted to site on injury also produce chem- cause release of histamine. Kinins (causes vasodilation & increased permeability of blood vessels)- present in blood plasma. once activated- play a role in chemotaxis- attract to injured area. Prostaglandins- released by damaged cells- intensify effects of histamine and kinins, help phagocytes move through capillary walls. Certain chemicals attract neutrophils to site of injury-chemotaxis- include chemicals produced by microorg or other neutrophils, kinins, leukotrienes, chemokines, comp of complement syste, Chemokines and cytokines are chemotatic for phagocytes and t cells stimulate inflame and immune, steady stream of neutrophils ensured by prod and released of granulocytes from bone marrow.
