BIOL-4610 Lecture Notes - Lecture 14: Lmna, Tethering, Cdc25
Document Summary
Intermediate filaments: lie just underneath nuclear membrane, have helical segment and globs, mesh network of lamin, supports nuclear membrane, lamin a, b, and c, cyclin b / cdk1. April 12, 2018: apc/c and ubiquitination at the end of mitosis, metaphase, degradation, securin is inhibitor of separase, allows sister chromatids to separate, anaphase. Induces dna repair enzymes: can induce p21 (sic1 same thing, sic1/p21 is the inhibitor of the s phase cyclins, dna replication checkpoint, make sure each chromosome is completely duplicated. If they"re (cid:374)ot you"ll ha(cid:448)e a repli(cid:272)atio(cid:374) fork so that you have some remaining single stranded dna: atp binds to single stranded dna. Inhibitor: activates the apc/c, allows for the nuclear envelope to reform, have chromatids separated far enough to undergo telophase and cytokinesis. In interphase and early mitosis, cdc14 is sequestered in the nucleolus: nucleolus is held by lipid anchors.
