MIP 315A Lecture Notes - Dendritic Cell, Mast Cell, B Cell
16 May 2014
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Document Summary
A defensive response of vascularized living tissue to cellular injury caused by endogenous or exogenous agents. Signs of inflammation rubor, calor, tumor, dolor. One reason skin turns red is that blood vessels get larger / closer to the surface. Affected by pathogenesis, allergens, stem cell factor, &c. All cause increased vascular permeability, smooth muscle contraction. Leukotrines and phosphoglandins created by mast cell maintain inflammation, pain. Macrophage gathers and kills bacteria, increases, inflammation results in more macrophages in the area. Oxygen independent mechanisms lysozyme, lactoferrin which chelates iron required for bacterial growth, cationic proteins, and the low ph inside phagocytic vacuoles. Most dead cells in an abscess neutrophils. Giant cells are present in granulomas, most dead cells macrophages. 7 10 days no response (lag phase) Response for a few weeks; igm antibody is present. Boost at end of that response (same sort & a new sort) 3 day lag phase and then a high response; igg for same sort.
