MIP 342 Lecture Notes - Dendritic Cell, Microglia, Mhc Class Ii

• School: CSU
• Department: Microbio, Immun, Pathology
• Course: MIP 342
• Professor: Alan Schenkel

Document Summary

Hyper-variable regions loops at tips of variable region. Hydrogen bonds hydrogen shared between electronegative atoms (n, o) Van der waals forces fluctuations in electron clouds around molecules oppositely polarize neighboring atoms. Hydrophobic forces hydrophobic groups interact unfavorably with water and tend to pack together to exclude water molecules. The attraction also involves van der waals forces. Aromatic rings (i. e. tyrosines), especially contribute vdw and hydrophobic binding. Fab variable region, of a heavy chain with a light chain. F(ab")2 still bivalent, crosslinks molecules pfc" recognized by fc-receptors. Mouse monoclonal (mab [monoclonal antibody]) recognized as foreign. Mouse variable regions fused with human igg constant regions. Can either upregulate cd8+ t cells (th1) or b cells (th2) Primarily recognize virally infected cells or foreign cells/some tumors. Helper t cells cd4, mhc class ii. Cytotoxic t cells cd8, mhc class i. Antigens (self and foreign) are presented to cd4 and cd8 t cells tcr. Recognition of foreign antigens activates the t cells.