BIOL 031 Lecture Notes - Lecture 8: Carbonic Anhydrase, G Cell, Intrinsic Factor
30 Jul 2020
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Protein that binds + allows for absorption of vit b12. Must take synthetic intrinsic factor to get vit b12. Hormone that stimulates secretion of gastric acid. Carbs + lipids not significantly chemically digested in stomach. Kills most bacteria that enter w food. Co2 + hco3 h2co3 hco3. Insertion of h+/k+-atpase into apical mem of parietal cells. # of pump proteins h+ pumped into stomach lumen. Proteins buffer h+ stomach ph a bit stop (-) feedback on acid secretion gastrin. H+ from parietal cell stomach lumen. K+ from stomach lumen parietal cell. Cl- diffuses from parietal cell stomach lumen. K+ diffuses from parietal cell stomach lumen. Cl- diffuses from blood parietal cell. Inactive don"t act on proteins inside cells that produce them protect cell from proteolytic damage. Secreted by parietal cells in stomach lining. Pepsinogen enters stomach lumen converted into pepsin. Signals that activated acid secretion also activate pepsinogen secretion. 20% of total protein digestion in stomach.
