BIOL 121 Lecture Notes - Lecture 24: Glycolysis, Myocyte, Oxidative Phosphorylation

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31 Aug 2020
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Rate of atp breakdown in skeletal muscle can change several hundred-fold from rest to activity. Only a small amount of atp is stored in muscle fibers. Thus, we need methods to rapidly reform atp. Stored creatine phosphate used immediately rephosphorylate adp to atp. High power, low capacity (only 10 seconds) Low power (10-25% of phosphagen) high capacity. Requires o2 (power limited by rate of o2 delivery) Atp formed via substrate level phosphorylation during breakdown of carbs via glycolysis. At the beginning of exercise, most energy from substrates stored within muscle fiber. Fatigue- decline in muscle tension as a result of previous muscle activity. Peripheral fatigue- decrease in force even though stimulation remains high. Central fatigue- decrease in force due to decrease in excitatory command sent to motor neurons (mentally not wanting to try as hard) Mass action effects of increase adp and pi. High tension and leaky sr cause damage/degradation of contractile proteins.

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