AS.280.335 Lecture Notes - Lecture 14: Toxicokinetics, Epigenome, The Barker
23 Jan 2017
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Document Summary
Very few chemicals have been tested for endocrine disruption by epa. Wide range of effects that exposure to these agents can have. Structural abnormalities newborn anomalies: fetus death or functional abnormalities. The degree of sensitivity to exposure to a toxic agent is greatest during organogenesis (when all of the organs are being made) Embryo is very sensitive to an agent that can cause toxicity. Exposure at one time in development can lead to altered tissue and organ function at a later time in development. Estradiol is the natural estrogen circulating in all of our bodies, although women have higher levels than men. Des is a synthetic estrogen (very high affinity for the estrogen receptor) More severe effects of des in women than men. Des is metabolized into reactive quinone metabolites that cause toxicity and dna damage (which can lead to mutation)
