BIO 325 Lecture Notes - Lecture 8: Tetany, Procaine, Cell Membrane

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16 Nov 2016
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Basics: rapid, local, reversal of membrane surface polarity, nerve membrane depolarizes as action potential approaches threshold, total depolarization: once threshold is reached, action potential goes all the way and the sodium channels open. When the membrane potential decreases or more forward, from a negative value to zero. Needs to be reached to generate action potential. Occurs when cell has depolarized by 1-20 millivolts. When threshold is reached the cell will continue to depolarize with o further stimulation: resting membrane potential. Inside the membrane becomes more negative compared to outside. If potassium concentration gradient is lost, rp no longer exists and no action potential is possible. 3 ways to stimulate: mechanical, electrical, chemical. Membrane potential: all body cells are electrically polarized. Inside of cell more negatively charged: differences in change is a result of differences in ionic icf and ecf. Potassium diffuses inward because resting membrane potential is more permeable to k. Differences is maintained by active transport through na/k pump.

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