BIOL 11000 Lecture Notes - Lecture 24: Citric Acid Cycle, Electrochemical Gradient, Intermembrane Space

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Oxidation of glucose (review: takes place in four phases, glycolysis, conversion of glucose pyruvate, oxidation of pyruvate, converted to acetyl-coa (if sufficient oxygen) In matrix of mitochondria: citric acid cycle (2c) acetyl + (4c) oxaloacetate (acetyl acceptor) (6c) citrate/citric acid, regenerations of oxaloacetate. All remaining high energy electrons are harvested: electron transport chain/chemiosmosis, oxidation of pyruvate + citric acid cycle + regeneration of oxaloacetate + electron. Location of events: glycolysis, occurs in cytoplasm, oxidation of pyruvate and citric acid cycle, occurs in matrix of mitochondria, electron transport chain, occurs in the inner mitochondrial membrane, proton gradient, builds up in the inner membrane space. Electron transport chain: electrons harvested from all previous steps are transferred to the electron transport. Chain: electrons power 3 proton pumps, protons are pumped from the matrix of mitochondria to the intermembrane space, the final electron acceptor is o2 to make h2o.

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