01:447:380 Lecture Notes - Lecture 10: Telomerase, Telomere, Semiconservative Replication
24 Jul 2016
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~solution have telomeres that you can afford to lose. ~replicative senescence for a cell cannot further replicate because telomere is gone, and then you would be losing genes so that cell just stops replicating. ~telomerase prevents cell from going into rep. senescence, found in germ line, stem, cancer cells. ~telomerase is a complex of protein and rna. ~telomerase has polymerase activity, it lays down an rna thing larger than original strand, and the extra gets replicated, continuing next to the original strand, by polymerase. ~methylation is not erased, gets passed down in replication of all cells. So the old dna is maintained in daughter copies. ~transcription slower in eukaryotes because have to unravel histone complex. ~alternative pslicing allows for different proteins to be made from same dna. ~microrna doesn"t code for protein but they"re basically genes.
