BICH 410 Lecture Notes - Lecture 16: Carbonic Anhydrase, Nfkb1, Cyanosis
Document Summary
F - helix shifting with enough hydrophobicity when rst oxygen binding occurs after the. Rst binding, the af nity of oxygen increases a1b1 dimer and a2b2 dimer interface forming the tetramer is a weaker interaction because it is only governed by ionic interactions and hydrogen bonds. R-state is stabilized by hydrophobic interactions. decreased pk = more acidic. The higher the h (lower the ph) concentration the further to the right the hb curve moves - causing a lower af nity for o2 and a higher p50 value. 1 bpg molecule per hb tetramer - forces the unloading of o2 so it cannot bond back. Quaternary shift narrows the central cavity so the bpg can be released. Fetal hb has a low bpg af nity - hb a2y2 (y chain has ser in place of his143) Bpg does not block off the binding of o2 * Bpg & co2 have negative affects towards the binding of o2.
