BIOL 3327 Lecture Notes - Lecture 24: Humoral Immunity, Integrin, Microsoft Powerpoint
15 Jul 2020
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Bh3: 5th powerpoint autoimmunity, released from lymphocyte after cell injury, bh3 binds to mitochondria, and said mitochondria subsequently leaks cytochrome c, cytochrome c activates capsase-9, which induces dna fragmentation and lymphocyte death (apoptosis) C1 inh: 3rd powerpoint humoral immunity, this is the complement cytokine that is missing in hanes disease, causes face, tongue and larynx edema. C1r2s2: 3rd powerpoint humoral immunity, second step of complement activation after the binding of c1 complex to antibodies, c1r2s2 cleaves c4. C4, c3, c5: 3rd powerpoint humoral immunity, involved in complement activation, first c4 is cleaved by c1r2s2, then c3 is formed, followed by the cleaving of c3, then c5 is formed, followed by the cleaving of c5. Fos and tnf receptors, inducing the release of capsase-8. Capsase-9: 5th powerpoint autoimmunity, after a lymphocyte is injured, bh3 is released, bh3 binds to the mitochondria, and the mitochondria then leaks cytochrome c, cytochrome c activates capsase-9 which causes dna fragmentation and death.
