BIOL 3327 Lecture Notes - Lecture 27: Interleukin 5, Immunoglobulin A, Antibody
15 Jul 2020
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Cd4+ cells are class ii mhc, cd8+ cells are class i mhc, a heterodimer is an antigen receptor of mhc-restricted cd4+ and cd8+ cells, the heterodimer is made of 2 polypeptide chains, designated tcr-alpha and. Tcr-beta, linked by a disulfide bridge: tcr binds to the mhc molecule. Nf-kb/ap-1: 2nd powerpoint cytokines, a signal is received from the tnf receptor, can result in nf-kb/ap-1 activation results in gene transcription/inflammation, or, it can result in apoptosis via capsase-8 activation. Ccr9 receptor and alpha-4-beta-7 integrin: when na ve cd4+ cells are exposed to tgf-beta and retinoic acid, they become regulatory t cells. Tfh: 2nd powerpoint cytokines, this cd4+ subset targets b cells to produce antibodies, expresses the same cytokines as th1/th2 cells. Tgf-beta: functions of tgf-beta: inhibits proliferation and function of t cells, subsequently inhibits macrophages, stimulates iga for iga class switching, promotes tissue repair.
