BIOL 3327 Lecture Notes - Lecture 52: Cardiac Glycoside, Endoplasmic Reticulum, Cardiac Muscle Cell

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If you have these increased free levels of calcium, we also need to remove them because they"re going to be high. We need to remove them so the heart won"t be in a constant state of total contraction. We have the na+/ca2+ exchanger and we also recapture the calcium in the sarcoplasmic reticulum. The sarcoplasmic reticulum catches a bunch of calcium and the na+/ca2+ exchanger removes some of the cytosolic calcium and exchanges it for one sodium. Then we have a lot of sodium on the inside of the cell and we need to get rid of that. The sodium balance is restored in the cell by the na+/k+ Atpase, so then for every na+ that goes out, we have a k+ come in again. Remember this requires energy; this is normal cardiac muscle cell contraction for how a muscle cell is contracting. Blockade of na+/k+ atpase at cardiac contractile cells. First step in how cardiac glycosides work.

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