BIO 205 Lecture Notes - Lecture 29: Cori Cycle, Hexokinase, Glucose Transporter
2 May 2018
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Lecture 29
Adrenalin initiates a series of reactions that inhibit Step 10 of glycolysis in
the liver
The cycle where glucose is converted into lactate and then converted back
to glucose in the liver, and finally transported back to the muscles is the Cori
cycle.
Regulated steps in glycolysis are all strongly downhill.
An example of an enzyme that is inhibited by its own product is muscle
hexokinase.
Organs which contain the enzyme for Bypass III of gluconeogenesis include
the liver.
The regulated steps in glycolysis are steps 1,3, and 10
The concentration of glucose in the blood is 5 mM
Insulin causes GLUT4 transported in muscle cells to move from the
cytoplasm to the plasma membrane
The reaction pyruvate -> lactate includes a C=O -> HC-OH conversion
Fermentation recycles NADH back to NAD+
Muscles lack receptors for glucagon
In muscle hexokinase, its Km is much smaller than the substrate, so its
active site is nearly always filled with substrate
The organ which is responsible for maintaining constant level of glucose in
the blood is the liver
An organ which uses glucose but not fatty acids as a fuel is the brain
An example of an enzyme that is inactivated by phosphorylation is liver
pyruvate kinase
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Document Summary
Adrenalin initiates a series of reactions that inhibit step 10 of glycolysis in the liver. The cycle where glucose is converted into lactate and then converted back to glucose in the liver, and finally transported back to the muscles is the cori cycle. Regulated steps in glycolysis are all strongly downhill. An example of an enzyme that is inhibited by its own product is muscle hexokinase. Organs which contain the enzyme for bypass iii of gluconeogenesis include the liver. The regulated steps in glycolysis are steps 1,3, and 10. The concentration of glucose in the blood is 5 mm. Insulin causes glut4 transported in muscle cells to move from the cytoplasm to the plasma membrane. The reaction pyruvate -> lactate includes a c=o -> hc-oh conversion. In muscle hexokinase, its km is much smaller than the substrate, so its active site is nearly always filled with substrate.
