PMY 302 Lecture 48: Androgen Pharmacology

• School: University at Buffalo
• Department: Pharmacology and Toxicology
• Course: PMY 302
• Professor: Bhattacharjee Arindam

Document Summary

Leydig cells: secrete testosterone in response to lh from the pituitary, t acts to feedback inhibit lh secretion. Sertoli cells: respond of fsh and t to promote spermatogenesis and production of factors such as inhibin b which acts to feedback inhibit pituitary fsh. Testosterone and dht exert actions via nuclear hormone androgen receptors for producing proteins sexual development, anabolic. Male hypogonadism and fsh production or testosterone production. Defined as a decrease in either of the two main functions of the testes: sperm. Hypergonadotropic hypogonadism: primary testicular failure, high levels of lh. Genetic: klinefelter syndrome, testosterone replacement therapy at normal. Hypogonadotropic hypogonadism: impaired hypothalamic gnrh, secondary to time of puberty testicular. Testosterone chemical modifications for pharmacology (all schedule iii) Increase solubility in oil so slowly into circulation and once in circulation, Drugs of choice for young boys it is hydrolyzed in plasma to testosterone with t1/2=30-60 minutes. Alkylation orally active when have methyl group.