BIL 255 Lecture Notes - Lecture 2: Atp Synthase, Oxidative Phosphorylation, Intermembrane Space

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Many carrier proteins: phosphate translocases, adp/atp translocases, pyruvate/h+ supporter. Lipid metabolism (beta oxidation) enzymes: outer membrane: contains large channel-forming proteins (porins), permeable. Diffuses molecules that are approximately 5,000 daltons: intermembrane space: this space contains several enzyme that use the atp passing out of the matrix to phosphorylate other nucleotides. Mitochondiral origin was likely by endosymbiosis: mitochondria originated from endosymbiotic purple bacteria, chloroplasts originated from endosymbiotic cyanobacteria, evidence. Ribosomal size and shape is the same as prokaryotes and different than eukaryotes: human mitochondrial dna. Only 13 out of 1,100 mito proteins are coded in the mitochondria, the rest are coded for by nucleus and made in cytoplasm. Mitochondrial dna also codes for some trna and rrna. 1000s of mito copies per cell, maternally inherited, lots of short tandem repeats, frequent point mutations, thus sequence analysis can indicate phylogeny. Homoplasmic (within an individual all the cells mitochondrial. Heteroplasmes (differ, one individual could have as many as: mtdna functions.

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