HSC 4624 Lecture Notes - Lecture 2: Pneumocystis Jirovecii, Airway Obstruction, Atypical Pneumonia

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A cooperative effort: respiratory system oxygenates blood and removes carbon dioxide, circulatory system transports gases in the bloodstream. System of tubes conduct air into and out of the lungs. Respiratory bronchioles: distal to terminal bronchiole with alveoli projecting from walls; form alveolar ducts and sacs; transport air and participate in gas exchange. Alveoli: o2 and co2 exchange; surrounded by alveolar septum; with cells that produce surfactant. Lung divided into lobes consisting of smaller units or lobules. Gases diffuse between blood, tissues, and pulmonary alveoli due to differences in their partial pressures. Large capillary surface area in contact with alveolar membrane. Pleura: thin membrane covering lungs (visceral pleura) and internal surface of the chest wall (parietal pleura) Pleural cavity: potential space between lungs and chest wall. Release of vacuum in pleural cavity leads to lung collapse. Referred as (cid:862)(cid:374)egati(cid:448)e pressure(cid:863) or su(cid:271)at(cid:373)ospheri(cid:272) (cid:271)e(cid:272)ause it is lesser tha(cid:374) at(cid:373)ospheri(cid:272) pressure. Tendency of stretched lung to pull away from chest creates a vacuum.

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