BIS 2A Lecture Notes - Lecture 25: Benign Tumor, Cell Plate, Cleavage Furrow

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BIS2A Lecture 25: The Cell Cycle and Mitosis
Cell Division
Cell division: the process by which one cell produces one or new more cells, mechanism
of reproduction for cells
o Usually involves the replication of DNA and other cellular components, and
division into two daughter cells
o Occurs in highly coordinated manner
Asexual Reproduction
Cell division in bacteria and archaea
o Binary fission: the process by which cells grow, duplicate major components such
as DNA and ribosomes, and divide into two identical daughter cells
Circular chromosome attached to the plasma membrane and origin of
replication near the attachment site
DNA replication occurs with both replication forks proceeding in
opposite directions
Cell elongates as DNA replicates, and elongating membrane pulls
chromosomes towards opposite ends of the cell
Formation of ring of FtsZ proteins near the middle of the cell that
accumulates other proteins that recruit membrane and cell wall materials
Formation of septum that divides cells into two daughter cells
o Process of binary fission strictly controlled but mechanisms remain not fully
understood
Cell cycle: coordinated process and mechanisms of control for cell division
o Interphase: cells perform cellular functions and prepare to divide, cells spend
majority of the cell cycle within interphase
G1 phase: growth and protein synthesis
S phase: DNA replication and formation of sister chromatids attached by
centromeres, duplication of centrosomes
G2 phase: growth and protein synthesis, duplication of organelles,
formation of microtubules for cell division
Prepares the cell for division
G0 phase: cells not actively dividing
Can be temporary under certain environmental conditions or
permanent (nerve cells)
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