PSC 101 Lecture Notes - Lecture 4: Cannabinoid Receptor Type 1, Rimonabant, Opioid Receptor
Document Summary
Psc 101 - lecture 4 neurophysiology (cont. ) and neuropharmacology. Anandamide a neurotransmitter produced by the brain. Tetrahydrocannabinol (thc) the psychoactive component of marijuana. Rats were trained to press a lever that delivered electrical stimulation to the hypothalamus (a rewarding stimulus) During training, some rats were treated with a drug that inhibits the activity of the. Inhibition of cb1 with the high dose of rimonabant reduced motivation to press the lever and also dopamine release. Although most neurotransmitters are released from axon terminals, there are exceptions. Ionotropic receptors fast, quickly change shape and open or close an ion channel when the transmitter molecule binds. Metabotropic receptors slow, when activated, they alter chemical reactions in the cell, using a system of second messengers to open an ion channel (may also start chemical reactions to change gene expression) Ligands fit receptors and activate or block them. Exogenous ligands drugs and toxins from outside the body.
