BIO SCI 45 Lecture Notes - Lecture 3: Aids, Reverse Transcriptase, Antiviral Drug
28 May 2016
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Mutations in hiv proteins due to high error rate of rt results in drugs no longer able to bind to those hiv proteins and thus the drug-resistant hiv escapes control and replicates. For the individual to take the drugs have been a problem especially in the late 90"s- would take a day long process and never miss a treatment. Some of the drugs had strong negative side effects. Cost was a problem (around 15,000 a year for each individual) Long term side effects of nucleoside reverse transcriptase inhibitors: cardiovascular and heart disease- side effect of the protease inhibitors b/c they made lipid metabolism in individuals. All antivirals have a common problem drugs are constructed to precisely fir the targeted protein structure, to achieve specificity; however, with that structure changing due to mutation (rt), the drug no longer works. Current problem: about 25% of new infections are hiv that are drug resistant to multiple different drugs.
